Mesoporous (Organo)Silica Nanoparticles for Drug Delivery
by
Xavier Cattoën
Univ. Grenoble Alpes, CNRS, Grenoble INP, Institut Néel, 38000, Grenoble, France
Mesoporous Silica Nanoparticles (MSNs) have attracted tremendous interest for their potential application in nanomedicine. Indeed, they possess excellent features to be used as drug delivery vehicles such as a low toxicity, good rigidity, a large pore volume enabling the encapsulation of large amounts of drugs, and the possibility to easily functionalize their surface, for example for targeting cancer cells. Although a myr-iad of studies of nanosystems based on MSNs have been reported for drug delivery, many aspects still deserve further exploration, in order to improve the synthesis and understanding of such systems.
In particular, the mechanism of MSNs synthesis is still not completely understood, and a significant variability in the size and shape of nano-particles (NPs) is observed between reported syntheses. Furthermore, whereas important research has been devoted to small-pore pure-silica NPs, little has been done on large pores variants based on organosilica based NPs, and on the hydrolytic stability of such silica nanoobjects. In this presentation, I will discuss some simple mechanistic investigations on the synthesis of mesoporous NPs using pH monitoring and light scattering measurements. I will then describe the preparation of periodic mesoporous organosilica nanoparticles, which possess very interesting adsorption properties for small molecules. I will also focus on the synthesis and hydrolytic stability of large-pores MSN, and in particular I will present the synthesis of original Au@mSiO2 core-shell NPs with large pores, which can encapsulate proteins such as BSA, RFP and HRP.
It is our pleasure to invite you to join the ISGS eSeminar for October 2023, which will be delivered by Dr Xavier Cattoën on Tuesday 31 October. Xavier is a CNRS scientist and a member of the Optics and Materials Group at the Institut Néel, Grenoble, France. His research focuses on the synthesis of organosilica materials for application in drug delivery, bioimaging, sensing or catalysis, including the preparation and encapsulation of organic fluorophores in organosilica for bioimaging. Please click here and here to learn more about his research and interesting career journey.
Date: Tuesday 31 October 2023
Format:
- ZOOM (eSeminar link), Meeting ID: 307 291 6432 Passcode: A$b4v26
Time:
- 09:00 – Ottawa, USA, East Coast
- 10:00 – Chile, Brazil (São Paulo) and Argentina
- 13:00 – UTC
- 13:00 – UK, Portugal
- 14:00 – Central Europe, Sweden, Norway, Switzerland
- 15:00 – Romania, Israel, Eastern Europe, Ukraine
- 16:00 – Russia (Moscow, St Petersburg)
- 21:00 – China, Singapore, Malaysia
- 22:00 – Japan, Korea
- 23:00 – Australia (East Coast)
