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Phd Position in Biomaterials
Reference
Job Type Full-time
Job Status Sourcing
Date Posted Monday, 30 May 2016
Location ICCF- France
Duration 36 month
Company Information

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Website: http://
Job Description

Synthesis and characterization of multifunctional bioactive glass nanoparticles



charlotte.vichery@sigma-clermont.fr


jean-marie.nedelec@sigma-clermont.fr


Institut de Chimie de Clermont-Ferrand (France)


 


Bioactive glasses are materials with outstanding properties for bone tissue repair. Their specificity lies in the fact that they chemically bond with bone tissues and while getting dissolved, the ions released help with the repair process. These materials, composed of SiO2, CaO and sometimes P2O5, can be synthesized by soft chemistry routes. Sol-gel chemistry is a highly versatile route which allows synthetizing bioactive glasses with tailored chemical composition and morphology. Also, it gives rise to porous materials, with a higher specific surface area compared to glasses made at high temperature. This is of tremendous importance as a higher specific surface area implies a larger contact surface between biological fluids and the glass and thus faster ionic exchange and glass dissolution rates. Another way to increase bioactive glass specific surface area is to reduce the size of the produced objects to the nanometer scale.


 


These last years, the idea of producing multifunctional porous monoliths, both bioactive and magnetic, has emerged. The aim of such materials would be to combine bone tissue repair to cancerous cells destruction through magnetic hyperthermia, i.e. through a controlled and localized temperature increase which would destroy selectively cancerous cells, more sensitive than healthy cells. In this process, heat would be produced by the relaxation of magnetic nanoparticles placed in an alternative magnetic field. Moreover, some studies have shown a positive impact of magnetic particles dispersed in bioactive glass monoliths on osteoblasts adhesion, proliferation and differentiation.


 


The research project proposed here aim to synthesize nanoparticles with both bioactive and magnetic properties, with the purpose of using them to destroy cancerous cells close to their implantation site, combined to a fast an efficient bone tissue repair. Nanoparticles present not only the advantage of a high specific surface area but also a broad range of applications, from their use as-synthesized, to their dispersion into polymers, leading for example to macroporous composite monoliths or injectable systems.


 


This Ph-D project will involve new materials syntheses combined to their fine structural and magnetic characterization, along with bioactivity tests. Indeed, the comprehension of relationships between their crystalline structure, their morphology, chemical composition, specific surface area, the nature of bioactive glass – magnetic particles interfaces and magnetic and bioactive properties will be mandatory in order to modify synthesis protocols to obtain materials with improved performances.


 


The Ph-D student will synthesize and characterize these bioactive and magnetic glass nanoparticles. He will work at the Chemistry Institute of Clermont-Ferrand (ICCF, France) in the Porous Materials and Bioceramics group under the supervision of Pr. Jean-Marie Nédélec and Dr. Charlotte Vichery. The syntheses will be realized within the institute, along with morphology (Scanning Electron Microscopy, Dynamic Light Scattering, Gas Adsorption), structural (X-ray Diffraction, Raman and InfraRed Spectroscopy, Nuclear Magnetic Resonance Spectroscopy) and composition (Energy Dispersive X-ray Spectrometry) characterizations, with the support of the institute technological platform and 2MATech. Preliminary bioactivity tests, implying the immersion of synthesized composites into biological fluid substitutes, will also be realized at the institute.


 


Magnetic properties will be evaluated in collaboration with the Laboratoire de Physique de la Matière Condensée (Ecole Polytechnique, Palaiseau, France) and cytotoxicity and bioactivity tests will be conducted by the C-Biosenss team (Université d’Auvergne, Clermont-Ferrand, France). The Ph-D student will also take part and/or assist to these experiments.

How to Apply send CV to jean-marie.nedelec@sigma-clermont.fr and charlotte.vichery@sigma-clermont.fr

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